[BCL11A represses HbF expression and varies during ontogeny].
نویسنده
چکیده
منابع مشابه
Transcription. Gene expression--where to start?
then the causative SNP either has a non–tissue-specific effect on transcription, or it acts at the posttranscriptional level, an issue that remains to be resolved. Although the results are consistent with the long isoforms of BCL11A functioning to suppress HbF production in a dose-dependent manner, they do not distinguish between a direct effect on γ-globin gene expression and an indirect effec...
متن کاملHuman fetal hemoglobin expression is regulated by the developmental stage-specific repressor BCL11A.
Differences in the amount of fetal hemoglobin (HbF) that persists into adulthood affect the severity of sickle cell disease and the beta-thalassemia syndromes. Genetic association studies have identified sequence variants in the gene BCL11A that influence HbF levels. Here, we examine BCL11A as a potential regulator of HbF expression. The high-HbF BCL11A genotype is associated with reduced BCL11...
متن کاملBCL11A deletions result in fetal hemoglobin persistence and neurodevelopmental alterations.
A transition from fetal hemoglobin (HbF) to adult hemoglobin (HbA) normally occurs within a few months after birth. Increased production of HbF after this period of infancy ameliorates clinical symptoms of the major disorders of adult β-hemoglobin: β-thalassemia and sickle cell disease. The transcription factor BCL11A silences HbF and has been an attractive therapeutic target for increasing HbF...
متن کاملEstimation of the difference in HbF expression due to loss of the 5' δ-globin BCL11A binding region.
BCL11A was the focus of recent studies on its inhibiting effect when bound onto the β-globin cluster in the mechanism of hemoglobin switching and HbF downregulation. We examined a cohort of 10 patients displaying different HbF levels and short deletions within the γβ-δ intergenic region to find a possible correlation with the BCL11A binding site located 5' to the δ-globin gene. Precise characte...
متن کاملMicroRNA-486-3p Regulates γ-Globin Expression in Human Erythroid Cells by Directly Modulating BCL11A
MicroRNAs (miRNAs) play key roles in modulating a variety of cellular processes through repression of mRNAs target. The functional relevance of microRNAs has been proven in normal and malignant hematopoiesis. While analyzing miRNAs expression profile in unilineage serum-free liquid suspension unilineage cultures of peripheral blood CD34(+) hematopoietic progenitor cells (HPCs) through the eryth...
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عنوان ژورنال:
- Medecine sciences : M/S
دوره 25 5 شماره
صفحات -
تاریخ انتشار 2009